GROWTH ACCELERATION IN CHILDREN WITH CHRONIC RENAL FAILURE TREATED WITH GROWTH-HORMONE-RELEASING HORMONE (GHRH). PRELIMINARY RESULTS
TITANIA PASQUALINI1, JORGE FERRARIS2, PATRICIA FAINSTEIN-DAY3,
1 Sección de Endocrinología, Crecimiento y Desarrollo; 2 Sección
de Nefrología y
Key words:GHRH, Growth and renal disease
Growth retardation is a prominent clinical manifestation in children with chronic renal failure (CRF). Nine children with CRF (3 on conservative treatmen; 3 on dialysis and 3 after renal transplantation) aged 1.6 to 14.0 (x ± SE: 8.1 ± 1.4) years, were treated with twice daily subcutaneous injections of 26 ± 2.4 µg/kg/day growth-hormone- releasing-hormone [GHRH (1-29) NH2 Serono (Geref)] during 3 to 6 months. mean serum urea and creatinine remained stable, although 2 patients on conservative treatment showed a moderate increase in serum creatinine. At the start of the study, heigth SDS was - 2.2 ± 0.2 (x ± SE), growth velocity was 4.5 ± 1.0 cm/year (- 2.3 ± 0.6 DS for chronological age) and growth hormone (GH) response to acute GHRH test (1 µg/kg IV) was 62 ± 17,5 ng/ml. Five patients increased height velocity from 3.8 ± 0.7 to 8.0 ± 1.2 cm/year (paired t test, p < 0.05). The peak GH response to GHRH was significantly higher in the group of growth non-responders than in the responders (p < 0.05). In conclusion, 5 out of 9 short children with CRF, 3 onconservative treatment, 1 on dialysis and 1 post renal transplantation, showed imporved growth in response to GHRH therapy. No consistent effct on renal function was detected. GHRH may be an alternative therapy to increase growth velocity in patients with CRF.
de crecimiento en niños con insuficiencia renal crónica tratados con
el factor liberados de la hormona de crecimiento (GHRH). Resultados
preliminares. El retardo de crecimiento es frecuente en niños con
insuficiencia renal crónica (IRC).
Received: 27-XII-1995 Accepted: 22-V-1996
Postal address: Dr. Titania Pasqualini, Departamento de Pediatría, Hospital Italiano, Gascón 450, 1181 Buenos Aires, Argentina.